Dobutamine Injection

DOBUTASYS
Dobutasys, A Sympathomimetic agent (Which results in increased activity of-, heart), contains Dobutamine Hydrochloride Equivalent to Dobutamine 50mg/ml. andis availablein the market in a 5ml Ampoule containing Dobutamine 250mg/5mL.

Clinical Information
Dobutasys has a powerful stimulating effect on the heart and
increases Cardiac output, Excitability, and Rate. It also causes peripheral vasodilation and produces a fall in diastolic blood pre~sure and usually maintains or slightly increases systolic blood pressure. Dobutasys is used in the treatment of bradycardia in patients with heart block, as a stimulant following cardiac arrests, and to control attacks. In cardiogenic and endotoxic shock, Dobutasys is used to treat patients who have failed to respond to\\\' replacement of electolyte or water deficiencies. Dobutasys stimulates the central nervous system.

Mode of Action
Dobutasys increases contractility and heart rate by stimulating adregeneic receptors in the cardiac tissues.

Dosage and Administration
Dobutasys is administered by LV Infusion only after considerable dilution. In Acute heart failure, the dose of DOBUTASYS, varies from 2.5-10mcg/Kg Body weight per min. according to patient\\\'s heart rate, cardiac and urine output. It should not come in interaction with an alkaline
solution.

Contraindications and Special Precautions
The administration of Dobutasys is contraindicated in
hypersensitivity, idiopathic hypertrophic subaortic stenosis. Dobutasys should be administered with extreme precaution in pregnant woman and neonates. There is an increased risk of rapid ventricular response in patients with atrial fibrillation. Causes cardiac arrythmias and hypotension which can prove fatal.

Drug Interactions
Increased cardiac output when used with nitroprusside. Increased vasopressor effect of dobutamine when used with bretylium, guanethidine, and oxytocic drugs.

U.S.P.
Following CPB, dobutamine in Dobutasys produces less tachycardia and a greater increase in Cardiac Index than isoprenaline. Dobutasys probably produces less tachycardia than dopamine after CPB, with a greater reduction in preload.